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11 found
Research
A 147-neonate Malawi trial found lower adjusted skin bacterial load with 1% chlorhexidine than standard care. Clinical benefit remains untested.
OpenResearch
In a prospective single-center study of 150 suspected-sepsis events, presepsin separated culture-confirmed sepsis poorly at the initial assessment (AUC 0.62, 95% CI 0.48–0.76). Its cohort-derived cutoff traded 73% sensitivity for only 42% specificity; CRP discriminated better here, but neither marker can carry the sepsis decision alone.
OpenResearch
In a prospective single-center cohort of 168 term neonates meeting sepsis criteria, 23 died within 28 days. FIBTEM clot firmness was lower in non-survivors, but adding it to nSOFA plus INR raised model AUC only from 0.862 to 0.878; the 0.016 gain was not statistically significant (DeLong P=.455). ROTEM described a hypocoagulable severity phenotype, not a validated stand-alone mortality tool.
