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Learning set
Two large randomized trials found no improvement in patient-important outcomes when repeated high-dose erythropoietin was added to therapeutic hypothermia for moderate or severe neonatal HIE.
OpenClinical tool
Web readyTherapeutic hypothermia eligibility checklist
OpenResearch
In 313 infants with moderate or severe HIE, death or moderate/severe developmental deficit occurred in 34.1% with erythropoietin and 28.7% with placebo (RR 1.19, 95% CI 0.84–1.68). Together with HEAL, PAEAN weakens the efficacy case while leaving rare-harm uncertainty.
Open