Research
SMOF and BPD: a striking signal, not a practice-changing answer
NICU360 Evidence Desk·6 min read·00
A new cohort reports lower adjusted BPD odds with SMOF—but the raw result, historical design, safety signals, and inconsistent effect estimates demand restraint.
THE HOT TAKE
This is a signal worth testing, not a reason to rewrite the lipid protocol tomorrow.
A May 2026 single-center cohort compared 96 preterm infants who received SMOF with 75 who received an MCT/LCT lipid emulsion. BPD occurred in 33.3% versus 46.7%. That 13.3-point raw difference is clinically interesting, but its unadjusted P value was 0.07.
BPD
NEC
Late sepsis
SMOF (n=96)MCT/LCT (n=75)
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